Women beat Men by ~6% in Weight Loss on Tirzepatide and Semaglutide

Hey everyone — quick research share, because this one is directly relevant to a lot of our patients.

A landmark trial just published in the New England Journal of Medicine gave us the clearest head-to-head yet: Tirzepatide vs Semaglutide, 751 adults, 72 weeks, everyone with overweight or obesity plus at least one weight-related condition.

The numbers: Tirzepatide patients lost an average of about 50 pounds (~20% of body weight) versus about 33 pounds (~14%) on Semaglutide. Waist circumference told the same story — 7 inches gone versus 5. And nearly one in three Tirzepatide patients lost at least a quarter of their body weight, versus one in six on Semaglutide.

But here's the finding that got my attention: across BOTH medications, women lost about 6% more than men. On average, women simply responded better to these treatments.

Now, I'll be straight with you, like always — averages aren't destinies. We see plenty of men at our clinics lose spectacularly on either medication, and individual response varies way more than any group average. What trials like this actually tell you is that these medications work, at scale, across very different bodies.

The real-world translation from 1,300+ patients: pick the medication with your provider based on YOUR response and tolerance, not on headlines — then give it time to work. The people who do best are the ones still consistent at month six, whichever molecule they're on.

(original research as always at the bottom of my summary)

-Daryl

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