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Instant Inflammation relief starting from very 1st Injection...

Semaglutide and Tirzepatide are not just “weight loss shots” – this new Journal of Clinicial Investigation (full link at end) recently pubhished reearch report shows they actively calm inflammation throughout the body, and some of these anti-inflammatory effects start within hours of the very first dose, well before any meaningful weight loss happens.


Why this research matters

Researchers summarize dozens of preclinical and clinical studies showing that GLP-1 medicines like semaglutide and tirzepatide lower key inflammatory markers such as C‑reactive protein (CRP) and TNF‑α in people with obesity and type 2 diabetes. In models, a single dose was enough to reduce inflammatory cytokines within hours, highlighting that the body’s immune system responds almost immediately once GLP‑1 signaling is activated.


Importantly, trial data suggest only 20%–60% of the inflammation reduction can be explained by weight loss and glucose control, meaning the medications have powerful direct anti-inflammatory actions of their own.


Benefits beyond the scale

The research outlines evidence that GLP-1 medications help quiet inflammation in the heart, blood vessels, liver, kidneys, joints, and even the brain. That helps explain why patients on GLP-1s see fewer heart attacks and strokes, improvements in metabolic liver disease, better kidney outcomes, and reduced severity of conditions like osteoarthritis and sleep apnea in large outcome trials.


For our patients, this can translate into less joint pain, easier breathing, more energy, better mobility, and protection for vital organs—even early in treatment while the “big” weight loss is still ahead.


Why joining our clinic matters

At our clinics in Puyallup and Federal Way, GLP-1 therapy is never “just a prescription.” Patients receive careful dosing, in-person follow-up, and coaching designed to maximize not only weight loss but also these critical anti-inflammatory and organ-protective benefits highlighted in the JCI article.


If you are living with extra weight, fatigue, joint pain, or inflammation-related conditions, this new science reinforces that GLP-1 medications can be truly life-changing when used in a supervised, comprehensive program like ours. If you are already with us, you made a wise decision; if you are still on the fence, now is the perfect time to schedule a consultation and let our team help you feel better from the inside out.


Daryl and Jennifer Welsh


Pacific Northwest Medical Group

6622 112th ST E, Puyallup WA 98373

253-340-2270


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